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AOD-9604 (Anti-Obesity Drug 9604) is a modified fragment of human growth hormone comprising amino acids 177-191. This 15-amino-acid peptide was originally developed to study fat metabolism without affecting IGF-1 levels or insulin resistance. Research has investigated its potential lipolytic effects and its role in cartilage and bone repair.
CAS #:221231-10-3
Molecular Weight:1815.08 g/mol
10 in stock
These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.
These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.
What purity and format is this AOD-9604 supplied in?
AOD-9604 is supplied as a lyophilized (freeze-dried) powder with a purity of ≥98% as determined by reverse-phase HPLC and confirmed by mass spectrometry. A certificate of analysis (CoA) documenting purity, molecular weight confirmation, and lot-specific quality data is provided with each order for the researcher’s reference.
What are the recommended storage conditions for AOD-9604?
Lyophilized AOD-9604 should be stored at −20°C in a dry, dark environment, where it remains stable for up to 24 months when kept sealed and away from repeated freeze-thaw cycles. Once reconstituted, aliquots should be stored at −80°C and used promptly; prolonged storage of reconstituted peptide is not recommended. These conditions are provided as general research guidance; researchers should validate stability under their specific laboratory conditions.
How is AOD-9604 typically reconstituted for in vitro research use?
For in vitro research applications, AOD-9604 is commonly reconstituted in sterile, bacteriostatic water or a dilute acetic acid solution (e.g., 0.1–1% acetic acid in water), followed by further dilution in appropriate physiological buffer (such as PBS) to the desired working concentration for experimental use. Researchers should optimize reconstitution conditions for their specific assay systems and confirm peptide integrity by analytical methods before use.
What in vitro and preclinical research models have been used to study AOD-9604?
Published preclinical research has employed primary adipocyte cell cultures, 3T3-L1 differentiated adipocytes, and rodent models of diet-induced obesity to investigate AOD-9604’s effects on lipid metabolism. Additional exploratory models have included chondrocyte cultures for connective tissue research. These systems are referenced in the scientific literature as tools for mechanistic investigation and are not predictive of human outcomes.
Is AOD-9604 suitable for human use or clinical application?
No. AOD-9604 supplied by this company is strictly for laboratory research and preclinical scientific investigation only. It is not approved by the FDA or any regulatory authority for human administration, therapeutic use, or dietary supplementation. It must not be used in humans or animals intended for human consumption.
What molecular targets are being investigated in AOD-9604 research?
Research has investigated AOD-9604’s interaction with beta-3 adrenergic receptors on adipocytes as a mechanistic pathway for its observed lipolytic activity in preclinical models. Studies have also examined its lack of meaningful affinity for the canonical growth hormone receptor (GHR) and its absence of IGF-1 axis stimulation, which distinguishes it mechanistically from full-length hGH in research contexts. Additional receptor-level investigations remain an active area of laboratory inquiry.
Scientific research has identified several key areas where AOD-9604 shows promising applications.
•Fat metabolism
•Lipolysis stimulation
•Adipose reduction
•Lipogenesis inhibition
•Cell regeneration
•Cartilage repair
•Bone density
•Collagen synthesis
•Tissue remodeling
•Joint repair
•Anti-inflammatory
•Cytoprotection
•Recovery support
These research findings represent ongoing studies and should not be interpreted as medical claims or recommendations.
These references are provided for research purposes only. Citations do not imply endorsement or approval of this product for any specific application.
