Klow BPC+ GHK-CU + KPV (10MG/50MG/10MG)

$159.00
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KLOW Overview

The KLOW Blend combines GHK-Cu, BPC-157, TB-500, and KPV into a single formulation studied for its potential influence on cellular repair and systemic regulation. The inclusion of KPV supports immune regulation and anti-inflammatory pathways.

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Quantity Discount (%) Price
1 - 2 Pieces — $159.00
3 - 4 Pieces 5 % $151.05
5 - 9 Pieces 10 % $143.10
10+ Pieces 15 % $135.15

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For Research Use Only

These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.

KLOW

Research Use Only

These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.

KLOW FAQ

KLOW is supplied as a lyophilized (freeze-dried) powder blend of KPV, GHK-Cu, BPC-157, and TB-500, each component produced at ≥98% purity by HPLC analysis. The lyophilized format maximizes stability during shipping and storage. A Certificate of Analysis (CoA) and mass spectrometry data are available upon request for laboratory verification.

The lyophilized KLOW blend should be stored at −20 °C in a desiccated environment, protected from repeated freeze-thaw cycles and light exposure. Under these conditions, the peptide components are expected to remain stable for up to 24 months. Once reconstituted, aliquots should be stored at 4 °C and used within a timeframe consistent with standard peptide handling protocols for each component peptide.

For laboratory use, KLOW is typically reconstituted in sterile bacteriostatic water or an appropriate aqueous buffer (e.g., PBS, pH 7.4). GHK-Cu is water-soluble; however, researchers should note that copper-chelated peptides may exhibit different solubility characteristics at varying pH. It is recommended to consult the individual solubility data for each constituent and prepare fresh working solutions or aliquots as required by the specific experimental protocol.

The four constituent peptides have been studied across a range of preclinical models: KPV has been evaluated in murine colitis models and epithelial cell lines; GHK-Cu has been studied in human fibroblast cultures, gene expression arrays, and CAM assays; BPC-157 has been investigated extensively in rodent tendon, gastrointestinal, and vascular injury models; and TB-500 has been examined in rodent cardiac, skeletal muscle, and wound-healing models. KLOW as a defined blend has not been independently characterized in the peer-reviewed literature to date and is provided to support novel investigational research.

No. KLOW is strictly a research compound intended for in vitro and preclinical laboratory use only. It is not approved, licensed, or intended for administration in humans or animals, and is not classified as a drug, supplement, or therapeutic agent. Researchers must comply with all applicable institutional, national, and regulatory guidelines governing the handling and use of research peptides.

Key molecular targets associated with the blend components include: MC1R and MC3R (KPV); copper-dependent metalloenzyme interactions, SPARC, and p53 signaling nodes (GHK-Cu); VEGFR2, FAK-paxillin, and nitric oxide synthase pathways (BPC-157); and G-actin sequestration via β-thymosin repeats and LIMK/cofilin pathways (TB-500). These targets collectively span inflammatory, angiogenic, and cytoskeletal signaling networks and represent the primary mechanistic focus areas for KLOW blend research.

KLOW Overview

The KLOW Blend combines GHK-Cu, BPC-157, TB-500, and KPV into a single formulation studied for its potential influence on cellular repair and systemic regulation. The inclusion of KPV supports immune regulation and anti-inflammatory pathways.

 

KLOW Structure

Research Findings

Scientific research has identified several key areas where KLOW shows promising applications.

 

Key Areas of Research:

Inflammatory Pathway Modulation:

  • •KPV, the C-terminal tripeptide of α-MSH, has been studied in vitro for its interaction with the melanocortin receptor MC1R and downstream NF-κB pathway inhibition in macrophage and epithelial cell models.

  • •GHK-Cu has been investigated for its capacity to modulate cytokine gene expression profiles, including TNF-α and IL-6, in cell culture systems.
  • •BPC-157 has been examined in rodent models for effects on nitric oxide signaling and eicosanoid pathways relevant to inflammatory cascades.
  • •The multi-peptide composition of KLOW presents a research opportunity to evaluate whether blended peptides exhibit additive, synergistic, or antagonistic effects on inflammatory markers in controlled in vitro assays.

Tissue Remodeling and Extracellular Matrix Research:

  • •GHK-Cu is among the most studied copper-binding peptides for its role in stimulating collagen and glycosaminoglycan synthesis in fibroblast cell models.
  • •TB-500 (a synthetic fragment of Thymosin Beta-4) has been investigated for actin-sequestration activity and its influence on cell migration assays relevant to wound-healing models.
  • •BPC-157 has been studied in rodent tendon and ligament explant models for effects on growth factor receptor expression including VEGFR2 and EGFR.
  • •Combined peptide blends such as KLOW offer a platform for investigating how multiple extracellular matrix-targeting sequences interact when presented simultaneously to primary dermal or connective tissue cells.

 

Angiogenesis and Vascular Biology Models:

  • •BPC-157 has been reported to upregulate VEGF and FAK-paxillin pathway components in in vitro endothelial tube formation assays.
  • •TB-500 has been evaluated in zebrafish and rodent models for its role in endothelial progenitor cell mobilization and blood vessel sprouting.
  • •GHK-Cu has been studied in chorioallantoic membrane (CAM) assays and fibroblast culture for pro-angiogenic gene expression profiles.
  • •KLOW as a blend provides a research construct for studying whether combinatorial peptide presentation alters angiogenic signaling relative to individual peptide controls.

 

Cell Survival and Oxidative Stress Research:

  • •GHK-Cu has been shown in gene array studies to regulate over 30 genes associated with antioxidant defense, including superoxide dismutase and metallothionein pathways.
  • •KPV has been examined in intestinal epithelial cell lines for its capacity to attenuate oxidative-stress-induced apoptosis markers.
  • •BPC-157 has been evaluated in models of reactive oxygen species (ROS) generation for effects on catalase and glutathione system activity.
  • •Multi-peptide blend formulations are of investigational interest for assessing whether additive ROS-modulating effects emerge in combined versus single-agent in vitro exposure paradigms.

These research findings represent ongoing studies and should not be interpreted as medical claims or recommendations.

References & Citations

  1. Dymek M, Olechowska K, Hąc-Wydro K. Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application. Pharmaceutics. 2023.PMID: 37896245
  2. Hu D, Zhang X, Gong S. An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant. Colloids Surf B Biointerfaces. 2025.PMID: 40716276
  3. Ogórek K, Nowak K, Wadych E. Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?. Molecules. 2025.PMID: 39795193
  4. Bian Y, Deng M, Liu J. The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6. Redox Biol. 2024.PMID: 38879894

These references are provided for research purposes only. Citations do not imply endorsement or approval of this product for any specific application.

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