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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded within the mitochondrial genome. As a mitochondrial-derived peptide (MDP), it represents a novel class of signaling molecules. Research has investigated its role in metabolic homeostasis, exercise-mimetic effects, insulin sensitivity, and cellular stress responses. MOTS-c is considered a key regulator of the nuclear genome by mitochondria.
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These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.
These products are for laboratory research only and not intended for medical use. They must be handled by qualified professionals in controlled laboratory environments. This compound has not been evaluated by the FDA and is not approved for human or veterinary use.
Third-party tested for purity, identity, and quantity.
Lot Number
VL-6063329
MOTS-c is supplied as a lyophilized (freeze-dried) powder with a purity of ≥98% as determined by high-performance liquid chromatography (HPLC). Each vial is accompanied by a certificate of analysis confirming purity, molecular weight, and sequence identity. This product is intended for laboratory research use only.
Lyophilized MOTS-c should be stored at -20°C in a desiccated environment, protected from light and moisture. Under these conditions, the lyophilized peptide is stable for up to 24 months. Avoid repeated freeze-thaw cycles once the peptide has been reconstituted.
For in vitro research applications, MOTS-c is typically reconstituted in sterile water or a dilute acetic acid solution (0.1–1% v/v) to achieve a stock concentration suitable for subsequent dilution in aqueous cell culture buffers. Researchers should consult the relevant primary literature and their own institutional protocols to determine appropriate working concentrations for their specific experimental systems.
Published preclinical studies have employed C2C12 skeletal muscle myotubes, primary hepatocytes, macrophage cell lines, and in vivo mouse models including high-fat diet and aged rodent models. These systems have been used to investigate metabolic, inflammatory, and stress-response endpoints relevant to MOTS-c biology.
No. MOTS-c supplied by this company is strictly for in vitro laboratory research and preclinical investigation. It is not approved by any regulatory authority for human or veterinary administration, and it is not intended for use as a drug, food additive, or dietary supplement.
Peer-reviewed research has associated MOTS-c with activation of AMP-activated protein kinase (AMPK) via accumulation of the endogenous metabolite AICAR through modulation of the folate-methionine cycle. Additional research has identified nuclear translocation of MOTS-c under stress conditions and interaction with nuclear transcriptional regulatory elements, suggesting roles in retrograde mitochondrial signaling.
Scientific research has identified several key areas where MOTS-C shows promising applications.
These research findings represent ongoing studies and should not be interpreted as medical claims or recommendations.
These references are provided for research purposes only. Citations do not imply endorsement or approval of this product for any specific application.
